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Women[ edit ] Hyperandrogenism, especially high levels of testosterone, can cause serious adverse effects on women's bodies if left untreated. High testosterone levels have been seen to be associated with obesity , hypertension , amenorrhea cessation of menstrual cycles , and ovulatory dysfunction, which can lead to infertility. The more prominent signs of hyperandrogenism are hirsutism unwanted growth of hair especially in the abdominal region and places on the back , acne after adolescence, deepening of voice, and alopecia balding. These effects have also been seen to have a large psychological impact on the individual, sometimes often leading to societal anxiety and depression , especially in adolescent girls and young women. Paired with obesity and hirsutism , it can cause the individual to have low self-esteem, and a poor view of oneself.
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Genetics[ edit ] Location and structure of the human androgen receptor: Top, the AR gene is located on the proximal long arm of the X chromosome. Middle, the eight exons are separated by introns of various lengths. Bottom, illustration of the AR protein, with primary functional domains labeled not representative of actual 3-D structure. Several case studies of fertile 46,XY males with AIS have been published,      although this group is thought to be a minority.
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